Madonna ? Animal (2010) 320 kb S ((TOP))
Many confounding factors can influence severity of radiation injury, namely, types of radiation, radiation duration, radiation dose rates, ages, genders, or existing health conditions. The mortality rate is positively correlated with types of radiation [30, 31], radiation doses [1, 15, 32, 33], and radiation dose rates . Female animals are considered to be more sensitive to radiation than male animals. In addition, younger animals are considered to be more radio-resistant than older animals . However, it is not clear whether pre-existing health conditions can directly influence the severity of radiation injury based on these findings.
Madonna – Animal (2010) 320 kb s
Overproduction of IL-6, NO, or nitrogen reactive species can cause dysfunction of the GI barrier [14, 27, 62, 63], resulting in bacterial entry into the systemic organs. In our laboratory, we collected heart blood and liver tissue from recently deceased or euthanized sham, wounded  or hemorrhaged , radiation-injured, or radiation combined-injured mice and cultured the tissue to determine if facultative bacteria had entered the circulation. Since tissues from healthy animals are normally sterile (except for occasional, transient bacteremia), the presence of bacteria in detectable numbers is indicative of systemic infection. 350c69d7ab